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1,2,3,6-Tetragalloylglucose
GENERAL CATALOGUE

1,2,3,6-Tetragalloylglucose

HY-111832 · 1 mg

MedChemExpress · Cat: HY-111832

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Catalog No: HY-111832
CAS No: 79886-50-3
Category: Metabolic Enzyme Protease
Pack Size: 1 mg
Brand: MedChemExpress

Description

1,2,3,6-Tetragalloylglucose TEgG is a competitive inhibitor of UDP-glucuronyltransferase UGT1A1, targeting the competitive substrate binding site of UGT1A1. 1,2,3,6-Tetragalloylglucose inhibits UGT1A1-mediated ?-estradiol 3-glucuronidation and SN-38 glucuronidation with IC50 of 6.01 ?M and 4.31 ?M, respectively, and binds to UGT1A1 with Ki of 3.55 ?M. 1,2,3,6-Tetragalloylglucose also induces tumor cell apoptosis, inhibit cell proliferation, activates caspase-3 and induces DNA fragmentation in HL-60 cells. 1,2,3,6-Tetragalloylglucose also inhibits HIV integrase and reverse transcriptase, and inhibits HCV protease.

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