1,4-Naphthoquinone-d6

Description

1,4-Naphthoquinone-d6 is the deuterium labeled 1,4-Naphthoquinone. 1,4-Naphthoquinone is an inhibitor with broad-spectrum inhibitory activity targeting DNA polymerase, NF-?B and monoamine oxidase MAO-A/B , with antibacterial and anti-biofilm efficacy. 1,4-Naphthoquinone is a competitive inhibitor of MAO-B Ki=1.4 ?M and a non-competitive inhibitor of MAO-A Ki=7.7 ?M . 1,4-Naphthoquinone inhibits DNA polymerase pol ?, ?, ?, ?, ?, ? with IC50 ranging from 5.57-128 ?M. 1,4-Naphthoquinone inhibits tumor cell proliferation, induces apoptosis and necrosis, and has anti-angiogenic and anti-inflammatory activities by inducing oxidative stress, depleting glutathione GSH , inhibiting DNA polymerase-mediated DNA synthesis and blocking NF-?B nuclear translocation. 1,4-Naphthoquinone can be used in anti-bacterial , anti-tumor and anti-inflammatory studies, including inhibition of melanoma and colon cancer cell growth and endothelial cell function, as well as LPS-induced inflammation models.