1-Formyl-beta-carboline

Description

1-Formyl-beta-carboline is an alkaloid with inhibitory activity against Newcastle disease virus NDV . 1-Formyl-beta-carboline can effectively inhibit different genotypes of NDV with IC50 values within 10 ?M, and its inhibition rate is more than 90 % at a concentration of 20 ?M. 1-Formyl-beta-carboline mainly exerts its effects by inhibiting the adsorption and entry processes in the NDV life cycle. 1-Formyl-beta-carboline has been identified as a novel HN inhibitor that can directly interact with the NDV HN protein and affect the adsorption of NDV. 1-Formyl-beta-carboline also inhibits the entry of NDV by inhibiting the PI3K/Akt signaling pathway rather than the ERK pathway.