1-Monopalmitin

Description

1-Monopalmitin Glyceryl palmitate is an activator of the PI3K/Akt pathway and an inhibitor of P-glycoprotein P-gp . 1-Monopalmitin can induce G2/M arrest and caspase-dependent apoptosis in cancer cells, while inhibiting IAPs protein expression. 1-Monopalmitin can increase drug accumulation by inhibiting P-gp activity in intestinal Caco-2 cells. 1-Monopalmitin has the ability to induce protective autophagy and apoptosis of lung cancer cells IC50=50-58 ?g/mL , with low toxicity to normal cells.