1(R)-(Trifluoromethyl)oleyl alcohol

Description

1 R - Trifluoromethyl oleyl alcohol compound R -24 is a trifluoromethyl alcohol derivative of Oleic acid HY-N1446 with activity in multiple models of Friedreich ataxia FRDA . 1 R - Trifluoromethyl oleyl alcohol inhibits ferroptosis induced by Erastin HY-15763 and decreases lipid peroxidation in NBT human myoblasts with frataxin FXN siRNA knockdown. 1 R - Trifluoromethyl oleyl alcohol at 40 ?M increases survival to 95 % in a model of FRDA where a significant percentage of cell death is caused by FAC HY-B1645 and BSO HY-106376 .