10-Butyl Ether Minocycline

Description

10-Butyl Ether Minocycline BEM , a Minocycline HY-17412A derivative, is an MMP-8 and MMP-9 inhibitor with IC50s of 69.4 AAasAasAAmuM and 47.0 AAasAasAAmuM, respectively. 10-Butyl Ether Minocycline suppresses LPS HY-D1056 -induced microglial activation. 10-Butyl Ether Minocycline inhibits VEGF-induced endothelial cell migration and L-Glutamine HY-N0390 -induced ROS levels. 10-Butyl Ether Minocycline significantly reduces alcohol consumption in the Chronic Intermittent Ethanol CIE mouse model of alcohol dependence. 10-Butyl Ether Minocycline can be used for the study of neuroimmune-inflammatory diseases and Alcohol use disorder AUD .