GENERAL CATALOGUE
10-SLF
HY-173082 · 50 mg
MedChemExpress · Cat: HY-173082
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Catalog No: HY-173082
CAS No: 2765058-89-5
Category: Apoptosis
Pack Size: 50 mg
Brand: MedChemExpress
Description
10-SLF is a PROTAC FKBP12 degrader. 10-SLF induces a ternary complex between FKBP12 and FBXW7-R465C, and promotes FBXW7-R465C-dependent proteasomal degradation of FKBP12. 10-SLF selectively reduces FKBP12 levels in cells expressing FBXW7-R465C. Pink: FKBP12 ligand HY-170988 ; Black: linker HY-W004640 ; Blue: E3 ligase ligand.
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