(10E,12Z)-Octadeca-10,12-dienoic acid

Description

10E,12Z -Octadeca-10,12-dienoic acid trans-10,cis-12 CLA2 is an orally active PPAR? activator and inhibits adipocyte differentiation. 10E,12Z -Octadeca-10,12-dienoic acid and its downstream metabolites have various antioxidant and antitumor activities. 10E,12Z -Octadeca-10,12-dienoic acid can induce proinflammatory cytokines and chemokines, which would lead to decreased adipogenesis and insulin resistance in adipose tissue. 10E,12Z -Octadeca-10,12-dienoic acid can affect many aspects of milk fat synthesis. 10E,12Z -Octadeca-10,12-dienoic acid reduces expression of lipogenic enzymes and inhibits the desaturation of fatty acids. 10E,12Z -Octadeca-10,12-dienoic acid can reduce lipoprotein lipase LPL activity in cultured 3T3-L1 adipocytes and enhance triacylglycerol release from these cells. 10E,12Z -Octadeca-10,12-dienoic acid decreases the expression of hepatic stearoyl-CoA desatyrase mRNA in mice. 10E,12Z -Octadeca-10,12-dienoic acid is associated with changes in mucosal NF-?B and Cyclin D1 protein levels in mice.