GENERAL CATALOGUE
(+/-)12-HEPE
HY-117044A · 25 g
MedChemExpress · Cat: HY-117044A
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medchemexpress.com/racemic-12-hepe.htmlCatalog No: HY-117044A
CAS No: 81187-21-5
Category: GPCR G Protein
Pack Size: 25 g
Brand: MedChemExpress
Description
AAasAasAA+/- 12-HEPE is produced by non-enzymatic oxidation of EPA. It contains equal amounts of 12 S -HEPE and 12 R -HEPE. The biological activity of AAasAasAA+/- 12-HEPE is likely mediated by one of the individual isomers, most commonly the 12 S isomer in mammalian systems. 12-HEPE inhibits platelet aggregation with the same potency as 12-HETE, exhibiting IC50 values of 24 and 25 ?M, respectively.1 These compounds are also equipotent as inhibitors of U46619-induced contraction of rat aorta IC50s=8.6-8.8 ?M .
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