GENERAL CATALOGUE
(1R)-IDH889
HY-112289B · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-112289B
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medchemexpress.com/1r-idh889.htmlCatalog No: HY-112289B
CAS No: 1429179-08-7
Category: Metabolic Enzyme Protease
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
1R -IDH889 is the isomer of IDH889 HY-112289 , and can be used as an experimental control. IDH889 is an orally available, brain penetrant, allosteric and mutant specific inhibitor of isocitrate dehydrogenase 1 IDH1 . IDH889 has potent selectivity for IDH1 R132 mutations, with IC50s of 0.02 ?M, 0.072 ?M and 1.38 ?M for IDH1R132H, IDH1R132C and IDH1wt, respectively. IDH889 shows potent cellular inhibition of R-2-hydroxyglutarate 2-HG production with an IC50 of 0.014 ?M.
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