2,3-Dihydro-3?-methoxynimbolide

Description

2,3-Dihydro-3?-methoxynimbolide is a limonoid compound isolated from the extracts of bark, leaves, roots, and seeds of Azadirachta indica A. Juss. var. siamensis Valeton. 2,3-Dihydro-3?-methoxynimbolide exhibits potent cyto-toxicities against one or more cell lines. 2,3-Dihydro-3?-methoxynimbolide activates caspases-3, -8, and -9, while increases the ratio of Bax/Bcl-2. 2,3-Dihydro-3?-methoxynimbolide induces apoptosis via both mitochondrial and death receptor pathways in AZ521.