2 -Azido-2 -deoxycytidine

Description

2AAasAasAa-Azido-2AAasAasAa-deoxycytidine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc. 2AAasAasAa-Azido-2AAasAasAa-deoxycytidine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction CuAAc with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition SPAAC reactions with molecules containing DBCO or BCN groups. 2AAasAasAa-Azido-2AAasAasAa-deoxycytidine is an azidonucleoside,and it should be phosphorylated twice to become an inhibitor of the nucleotide reductase.