GENERAL CATALOGUE
2-(Cyclohexylmethyl)-plumbagin
HY-169830 · 1 mg
MedChemExpress · Cat: HY-169830
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medchemexpress.com/2-cyclohexylmethyl-plumbagin.htmlCatalog No: HY-169830
CAS No: 3033734-59-4
Category: Apoptosis
Pack Size: 1 mg
Brand: MedChemExpress
Description
2- Cyclohexylmethyl -plumbagin is a derivative of the naphthoquinone compound Plumbagin HY-N1497 . Under nutrient-deprived conditions, 2- Cyclohexylmethyl -plumbagin selectively exhibits cytotoxicity against PANC-1 human pancreatic cancer cells PC50 = 0.11 AAasAasAAmuM and reduces the phosphorylation of Akt and mTOR in PANC-1 cells. 2- Cyclohexylmethyl -plumbagin also induces apoptosis Apoptosis in PANC-1 cells at a concentration of 1 AAasAasAAmuM. Additionally, 2- Cyclohexylmethyl -plumbagin reduces tumor volume and weight in a xenograft MiaPaCa-2 pancreatic cancer mouse model.
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