2'-Deoxy-2'-fluorouridine

Description

2-Deoxy-2-fluorouridine is a derivative of the pyrimidine nucleoside uridine. 2-Deoxy-2-fluorouridine is a nucleoside analog that inhibits the replication of wild-type viruses by binding to the viral RNA. Hepatitis C polyU/UC RNA strands containing 2-Deoxy-2-fluorouridine, bind to RIG-I but do not activate RIG-I signaling in a reporter assay using Huh7 cells. 2-Deoxy-2-fluorouridine also has been used as a starting material in the synthesis of respiratory syncytial virus RSV polymerase inhibitors. 2-Deoxy-2-fluorouridine can incorporate into DNA and RNA in rat and woodchuck model upon administration. 2-Deoxy-2-fluorouridine can be studied in anti-viral research.