2'-Deoxyuridine (Standard)

Description

2-Deoxyuridine Standard is the analytical standard of 2-Deoxyuridine. This product is intended for research and analytical applications. 2AAasAasAa-deoxyuridine is a brain-penetrant pyrimidines nucleotide that is associated with nervous system diseases. 2-Deoxyuridine could increase chromosome breakage and results in a decreased thymidylate synthetase activity. 2-Deoxyuridine is a precursor in the synthesis of Edoxudine HY-B1011 and also an analogue of 5-ethynyl-2-deoxyuridine, EdU HY-118411 . 2AAasAasAa-deoxyuridine reduces microglial activation and improve oxidative stress damage by modulating glycolytic metabolism on the A?25-35-induced brain injury, which is promising for research of AlzheimerAAasAasAas disease AD . In Vitro:The interaction between the 2-deoxyuridine and the column increases the duration of retention of 2-deoxyuridine. Gradient elution with sodium acetate buffer-ACN eluent on two ZIC-HILIC homemade columns separates 2-deoxyuridine in under 9 min. In Vivo:2-Deoxyuridine 34.42 ng/mL, gavage, 15 min passes the blood-brain barrier BBB to enter the hippocampus of mice brain. 2-Deoxyuridine 20 mg/kg, gavage, daily for 4 weeks improves cognition and memory loss and attenuates the damage to the hippocampus in A?25-35-induced mice model.