GENERAL CATALOGUE
22-SLF
HY-163807 · 5 mg
MedChemExpress · Cat: HY-163807
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Manufacturer product page
medchemexpress.com/22-slf.htmlCatalog No: HY-163807
Category: Apoptosis
Pack Size: 5 mg
Brand: MedChemExpress
Description
22-SLF is a PROTAC degrader, that degrades FK506-binding protein 12 FKBP12 with a DC50 of 0.5 AAasAasAAmuM. 22-SLF interacts with C227 and C228 in FBXO22 to induce a ternary complex between FKBP12 and FBXO22, and degrades FKBP12 in a FBXO22-dependent manner. 22-SLF can be used for fundamental cancer research as a probe to study the FBXO22 degradation pathway. Pink: FKBP12 ligand HY-114872 ; Black: Linker HY-163821 ; Blue: FBXO22 ligand HY-163826 .
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