GENERAL CATALOGUE
3?,5?-DiOA-dC
HY-172533 · 50 mg
MedChemExpress · Cat: HY-172533
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medchemexpress.com/3-5-dioa-dc.html
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Catalog No: HY-172533
Category: Immunology Inflammation
Pack Size: 50 mg
Brand: MedChemExpress
Description
3AAasAasAa,5AAasAasAa-DiOA-dC is a hydrophobic nucleotide lipid and a ligand for the STING agonist c-di-GMP CDG . 3AAasAasAa,5AAasAasAa-DiOA-dC can assemble with CDG and form stable cyclic dinucleotide nanoparticles via various supramolecular forces driven by molecular recognition. 3AAasAasAa,5AAasAasAa-DiOA-dC can decrease tumor weight and volume, increase CD8 T cell, neutrophils as well as NK cell counts in tumor microenvironment in combination with CDG. 3AAasAasAa,5AAasAasAa-DiOA-dC also increases the levels of TNF-? and IFN-? in murine melanoma model.
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