3-AP-Me

Description

3-AP-Me is a dimethyl derivative of the nucleotide reductase inhibitor 3-AP SML0568 . 3-AP-Me can activate the endoplasmic reticulum ER stress pathway by promoting the phosphorylation of eIF2? and increasing the gene expression of transcription factors ATF4 and ATF6, leading to cell apoptosis. Additionally, 3-AP-Me can activate the stress kinases c-Jun N-terminal kinase JNK and p38 mitogen-activated protein kinases. 3-AP-Me also leads to the upregulation of the spliced mRNA variant XBP1, can be used in cancer research.