3?-Azido-2?,3?-dideoxyuridine

Description

3?-Azido-2?,3?-dideoxyuridine AzdU is a nucleoside analog of Zidovudine HY-17413 . 3?-Azido-2?,3?-dideoxyuridine is a potent inhibitor of human immunodeficiency virus HIV replication in human peripheral blood mononuclear cells PBMC with limited toxicity for human bone marrow cells BMC . 3?-Azido-2?,3?-dideoxyuridine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction CuAAc with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition SPAAC reactions with molecules containing DBCO or BCN groups.