3 -Azido-3 -deoxy-2-thiouridine

Description

3AAasAasAa-Azido-3AAasAasAa-deoxy-2-thiouridine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc. 3AAasAasAa-Azido-3AAasAasAa-deoxy-2-thiouridine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction CuAAc with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition SPAAC reactions with molecules containing DBCO or BCN groups.