3'-Azido-3'-deoxy-5-methylcytidine

Description

3-Azido-3-deoxy-5-methylcytidine CS-92 is a potent xenotropic murine leukemia-related retrovirus XMRV inhibitor with a CC50 of 43.5 ?M in MCF-7 cells. 3-Azido-3-deoxy-5-methylcytidine also inhibits HIV-1 reverse transcriptase with an EC50 of 0.06 ?M in peripheral blood mononuclear PBM cells. 3-Azido-3-deoxy-5-methylcytidine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction CuAAc with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition SPAAC reactions with molecules containing DBCO or BCN groups.