(3R,10R,14aS)-AZD4625

Description

3R,10R,14aS -AZD4625 is the isomer of AZD4625 HY-146223 , and can be used as an experimental control. AZD4625 is an orally active, selective irreversible, covalent allosteric GTPase KRASG12C inhibitor with an IC50 of 3 nM. AZD4625 can inhibit the MAPK pathway with decreased pCRAF, pMEK, and pERK and the PI3K pathway with decreased pAKT and pS6 , and induce cell apoptosis. AZD4625 has no binding and inhibition of wild-type RAS or isoforms carrying non-KRASG12C mutations. AZD4625 can be used for the study of KRASG12C mutant non-small cell lung cancer.