(3S,5R)-Rosuvastatin

Description

3S,5R -Rosuvastatin is the 3S,5R -enantiomer of Rosuvastatin. Rosuvastatin is a competitive HMG-CoA reductase inhibitor with an IC50 of 11 nM. Rosuvastatin potently blocks human ether-a-go-go related gene hERG current with an IC50 of 195 nM. Rosuvastatin reduces the expression of the mature hERG and the interaction of heat shock protein 70 Hsp70 with the hERG protein. Rosuvastatin is very effective in lowering low-density lipoprotein LDL cholesterol, triglycerides, and C-reactive protein levels.