(+/-)5,6-DHET lactone

Description

5,6-DiHET lactone AAasAasAA+/- 5,6-DiHETrE lactone is a lactonized form of 5,6-EET and 5,6-DiHET. In solution, 5 6 -EET degrades into 5 6 -DiHET and 5 6 -?-lactone, which can be converted to 5 6 -DiHET and quantified by GC-MS.1 5,6-DiHET potently induces vasodilation of isolated canine coronary arterioles, with 41 and 100 % inhibition occurring at 0.01 and 100 pM, respectively. It also induces vasodilation in isolated human microvessels and increases intracellular calcium levels in a dose-dependent manner, an effect that can be blocked by the nitric oxide scavenger L-NAME.