5,6-Epoxyeicosatrienoic acid

Description

5,6-Epoxyeicosatrienoic acid 5,6-EET; AAasAasAA+/- 5,6-EpETrE is a fully racemic version of the enantiomeric forms biosynthesized from arachidonic acid by cytochrome P450 enzymes. In solution, 5,6-Epoxyeicosatrienoic acid degrades into 5,6-DiHET and 5,6-?-lactone, which can be converted to 5,6-DiHET and quantified by GC-MS. In neuroendocrine cells, such as the anterior pituitary and pancreatic islets, 5,6-Epoxyeicosatrienoic acid has been implicated in the mobilization of calcium and hormone secretion. 5,6-Epoxyeicosatrienoic acid is an inhibitor of T-type voltage-gated calcium channels Cav3 that inhibits isoforms Cav3.1, Cav3.2 IC50=0.54 ?M , and Cav3. and decreases nifedipine-resistant phenylephrine-induced vasoconstriction in isolated mouse mesenteric arteries via Cav3.2 blockade when used at a concentration of 3 ?M. In addition, it is a substrate of COX-1 and COX-2.