5-Fluoroorotic Acid Monohydrate-13C15N2

Description

5Fluoroorotic Acid Monohydrate13C15N2 is the isotope analog of 5Fluoroorotic Acid Monohydrate, 5FOA . 5FOA has become a valuable tool for research in the field of molecular genetics. It has been employed in the selection of resistant strains of Saccharomyces cerevisiae that possess a mutant URA3 gene which renders them orotidine5phosphate decarboxylase deficient. 5FOA is coverted to 5fluorouridine monophosphate 5FUMP in yeast cells, which can become incorporated into RNA or metabolized to the highly toxic 5fluoro2deoxyuridine monophosphate 5FdUMP . 5FdUMP is a potent inhibitor of thymidylate synthase TS , causing the cessation of DNA synthesis. More recently, 5FOA has been shown to possess potent antimalarial activity against both chloroquinesusceptible and chloroqu