5-HT1AR agonist 1

Description

5-HT1AR agonist 1 Compound A3 emerges as a relatively balanced multi-target activity profile, including 5-HT1AR agonist with an EC50 value of 34 nM, SERT reuptake ihibitor IC50 =12 nM , NET reuptake inhibitor IC50 =78 nM and DAT reuptake inhibitor IC50 =135 nM . 5-HT1AR agonist 1 performs significant antidepressant effects and exhibits excellent bioavailability and low clearance in mice, which is promising for research in the field of antidepressant drugs.