

HY-172258 · 50 mg
MedChemExpress · Cat: HY-172258
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medchemexpress.com/5-ht2b-antagonist-2.htmlDescription
5-HT2B antagonist-2 Compound 19c is a 5HT2B receptor antagonist with an IC50 of 1.09 nM. 5-HT2B antagonist-2 can downregulate the expression of fibrosis-related genes ?-SMA, Timp1, Col1a1, and Col3a1, and significantly reduce the deposition of fibrosis, thereby reducing the fibrotic area and inhibiting the fibrotic process in CCl4-induced liver fibrosis mouse models. 5-HT2B antagonist-2 can be used in the study of immune inflammatory-related diseases, particularly in the research of pulmonary fibrosis diseases.







