5-Hydroxymethylcytosine-13C,d2

Description

5-Hydroxymethylcytosine-13C,d2 is the 13C and deuterium labeled 5-Hydroxymethylcytosine HY-W018324 . 5-Hydroxymethylcytosine 5hmC is an oxidized forms of 5-methylcytosine 5mC in mammalian DNA. 5-Hydroxymethylcytosine is produced from 5mC in an enzymatic pathway involving three 5mC oxidases, Ten-eleven translocation TET 1, TET2, and TET3. The conversion of 5mC into 5hmC can be the first step in a pathway leading towards DNA demethylation. 5-Hydroxymethylcytosine is associated with gene transcription and frequently used as a mark to investigate dynamic DNA methylation conversion during mammalian development. 5-Hydroxymethylcytosine can be used for the study of non-small cell lung cancer NSCLC , neurodegenerative diseases AlzheimerAAasAasAas, ParkinsonAAasAasAas and hematological malignancies acute myeloid leukemia, myelodysplastic syndromes .