5-LOX/sEH-IN-1

Description

5-LOX/sEH-IN-1 Compound 8o is a dual 5-LOX/sEH-IN-1 inhibitor with cardioprotective effects, exhibiting IC50 values of 3.05 ?M and 2.20 nM respectively, and 5-LOX/sEH-IN-1 can also inhibit the activity of COX-2 IC50=10.50 ?M . 5-LOX/sEH-IN-1 has analgesic and anti-inflammatory effects, while reducing ulcer pathogenicity, and can be used to develop anti-inflammatory agents with fewer gastrointestinal and cardiovascular side effects.