7?,27-Dihydroxycholesterol

Description

7?,27-Dihydroxycholesterol is an oxysterol characterized by its oxidized side chains and is produced through the hydroxylation of 27-Hydroxycholesterol 27-OHC ; it serves as a metabolite of interest in lipidomic analyses of various pathological conditions, including neurological diseases, Smith-Lemli-Opitz syndrome, obesity metabolic syndrome, and diabetes. Notably, levels of 7?,27-di-OHC decrease following lipopolysaccharide activation, and it also functions as a ligand for Epstein-Barr virus-induced gene 2 EBI2 . Additionally, 7?,27-di-OHC exists as a structural isomer of 7?,25-dihydroxycholesterol 7?25-OHC .