7,4'-Dihydroxyflavone

Description

7,4-Dihydroxyflavone 7,4-DHF is a flavonoid, which can be isolated from Glycyrrhiza uralensis. 7,4-Dihydroxyflavone is eotaxin/CCL11 inhibitor and CBR1 inhibitor IC50=0.28 ?M . 7,4-Dihydroxyflavone has the ability to consistently suppress eotaxin production and prevent dexamethasone Dex ?paradoxical adverse effects on eotaxin production. 7,4-Dihydroxyflavone 7,4-DHF inhibits MUC5AC gene expression, mucus production and secretion via regulation of NF-?B, STAT6 and HDAC2.7,4-Dihydroxyflavone 7,4-DHF decreases phorbol 12-myristate 13-acetate PMA stimulated NCI-H292 human airway epithelial cell MUC5AC gene expression and mucus production with IC50 value of 1.4 AAasAasAAmuM.