7,4'-Dimethoxy-3-hydroxyflavone

Description

7,4-Dimethoxy-3-hydroxyflavone is an orally active PAR4 antagonist. 7,4-Dimethoxy-3-hydroxyflavone inhibits PAR4-mediated human platelet aggregation with an IC50 of 1.4 ?M. 7,4-Dimethoxy-3-hydroxyflavone inhibits PAR4-mediated human platelet aggregation and PAR4 signaling pathways, including NF-?B, Ca2+/protein kinase C, Akt, ERK and p38. 7,4-Dimethoxy-3-hydroxyflavone prevents vascular PAR4 expression, endothelial dysfunction and ameliorates oxidative stress in Streptozotocin STZ HY-13753 -induced diabetic mice. 7,4-Dimethoxy-3-hydroxyflavone prevents thrombosis in mice without affecting bleeding time 1 2 .