7?-Hydroxy-DHEA

Description

7?-Hydroxy-DHEA 7?-Hydroxydehydroepiandrosterone is a 7?-hydroxylated metabolite of DHEA HY-14650 , catalyzed by intracellular steroid 7?-hydroxylases such as P450 2A1. 7?-Hydroxy-DHEA exhibits biological activity comparable to DHEA but does not convert into compounds with androgenic or estrogenic activity. It induces the activity of thermogenic enzymes such as mitochondrial sn-glycerol-3-phosphate dehydrogenase and cytosolic malic enzyme, enhancing heat production and reducing food utilization efficiency. As a more efficient and safer metabolite compared to DHEA, 7?-Hydroxy-DHEA holds potential for studies in the fields of obesity, metabolic diseases, and adrenal carcinoma.