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7-Hydroxystaurosporine
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7-Hydroxystaurosporine

HY-13661 · 1 mg

MedChemExpress · Cat: HY-13661

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Catalog No: HY-13661
CAS No: 112953-11-4
Category: Apoptosis
Pack Size: 1 mg
Brand: MedChemExpress

Description

7-Hydroxystaurosporine UCN-01 is a synthetic derivative of Staurosporine HY-15141 with antitumor activity. 7-hydroxystaurosporine inhibits serine/threonine kinase AKT and calcium-dependent protein kinase C activity. 7-hydroxystaurosporine also activates indirectly cyclin-dependent kinases CDKs . 7-hydroxystaurosporine arrests tumor cells in the G1/S of the cell cycle and prevents nucleotide excision repair by inhibiting the G2 checkpoint kinase chk1, resulting in apoptosis.

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