8-(3-Chlorostyryl)caffeine

Description

8- 3-Chlorostyryl caffeine CSC is an adenosine antagonist with selective activity at the A2a adenosine receptor. 8- 3-Chlorostyryl caffeine showed 520-fold selectivity in radioligand binding experiments in rat brain. Antagonism of adenylylase by 8- 3-Chlorostyryl caffeine shows 22-fold selectivity in rat chromaffin cells When 8- 3-Chlorostyryl caffeine is co-administered with the A1-selective antagonist CPX, It can also further increase exercise activity. 8- 3-Chlorostyryl caffeine exhibits good MAO-B inhibitory activity in primate mitochondria. 8- 3-Chlorostyryl caffeine also has excellent A2A receptor affinity.