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(+/-)8(9)-EpETE
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(+/-)8(9)-EpETE

HY-130309 · 25 g

MedChemExpress · Cat: HY-130309

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Catalog No: HY-130309
CAS No: 851378-93-3
Category: Metabolic Enzyme Protease
Pack Size: 25 g
Brand: MedChemExpress

Description

Eicosapentaenoic acid EPA is converted to epoxyeicosatetraenoic acids EpETEs by several cytochrome P450 isoforms. The major product of this epoxygenase pathway, AAasAasAA+/- 17 18 -EpETE, relaxes vascular and airway smooth muscle by activating large conductance Ca2+-activated K+ BKCa channels by directly interacting with BK? channel subunits. AAasAasAA+/- 8 9 -EpETE is an epoxygenase pathway product produced from EPA by CYP450 both in vitro and in vivo.

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