8-pCPT-2?-O-Me-cAMP

Description

8-pCPT-2?-O-Me-cAMP 8-CPT-2-O-Me-cAMP , an analog of cAMP, is an activator of exchange proteins activated by cAMP Epac . 8-pCPT-2?-O-Me-cAMP activates Epac1 EC50 = 2.2 ?M , but not PKA EC50 10 ?M. 8-pCPT-2?-O-Me-cAMP stimulates Epac-mediated Ca2+ release in pancreatic ?-cells in vitro. 8-pCPT-2?-O-Me-cAMP is a Rap1 activator. 8-pCPT-2?-O-Me-cAMP enhances the retinal pigment epithelium barrier against the pathological choroidal endothelial cell invasion that occurs in macular degeneration.