GENERAL CATALOGUE
8-pCPT-2?-O-Me-cAMP sodium
HY-107543 · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-107543
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Catalog No: HY-107543
CAS No: 634207-53-7
Category: GPCR G Protein
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
8-pCPT-2?-O-Me-cAMP 8-CPT-2-O-Me-cAMP sodium, an analog of cAMP, is an activator of exchange proteins activated by cAMP Epac . 8-pCPT-2?-O-Me-cAMP sodium activates Epac1 EC50 = 2.2 ?M , but not PKA EC50 10 ?M. 8-pCPT-2?-O-Me-cAMP sodium stimulates Epac-mediated Ca2+ release in pancreatic ?-cells in vitro. 8-pCPT-2?-O-Me-cAMP sodium is a Rap1 activator. 8-pCPT-2?-O-Me-cAMP sodium enhances the retinal pigment epithelium barrier against the pathological choroidal endothelial cell invasion that occurs in macular degeneration.
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