9(R)-HODE

Description

9 R -HODE is a monohydroxy fatty acid and metabolite of linoleic acid. It is formed from linoleic acid by COX and lipoxygenase LO .9 R -HODE induces chemotaxis, increases the levels of chemokine C-C motif receptor 9 CCR9 and chemokine C-X-C motif receptor 4 CXCR4 , and inhibits IL-6 release in primary human monocytes. It inhibits CD3?- and CD28-induced proliferation of isolated human peripheral blood lymphocytes when used at a concentration of 25 ?g/mL.