GENERAL CATALOGUE
A-57696
HY-P2055 · 50 mg
MedChemExpress · Cat: HY-P2055
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Catalog No: HY-P2055
CAS No: 125598-87-0
Category: Metabolic Enzyme Protease
Pack Size: 50 mg
Brand: MedChemExpress
Description
A-57696 is a cholecystokinin antagonist with selective activity at cortical CCK-B receptors IC50 = 25 nM . A-57696 behaves as a competitive antagonist in reversing CCK8-stimulated pancreatic alpha-amylase secretion and phosphatidylinositol degradation. A-57696 fails to induce gallbladder contraction and inhibits CCK8-induced contraction. A-57696 behaves as a partial agonist at CCK-B/gastrin receptors on NCI-H345 cells, achieving 80 % of the maximal CCK8 response. A-57696 and CCK8 inhibit each other in a calcium mobilization assay.
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