A? aggregation modulator-1

Description

A? aggregation modulator-1 is a stimulator of amyloid-? A? fibrillogenesis. A? aggregation modulator-1 binds hydrophobic residues in A? peptides and stabilizes ?-sheet-rich protofibrils and fibrils. A? aggregation modulator-1 accelerates A? polymerization and reduces concentrations of small, toxic A? oligomers in heterogeneous aggregation reactions. A? aggregation modulator-1 suppresses long-term potentiation LTP inhibition by A? oligomers in hippocampal brain slices. A? aggregation modulator-1 can be used for the study of Alzheimers disease AD .