GENERAL CATALOGUE
A2AR-antagonist-1
HY-149916 · 50 mg
MedChemExpress · Cat: HY-149916
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Manufacturer product page
medchemexpress.com/a2ar-antagonist-1.htmlCatalog No: HY-149916
CAS No: 2922920-71-4
Category: GPCR G Protein
Pack Size: 50 mg
Brand: MedChemExpress
Description
A2AR-antagonist-1 compound 38 is an orally active adenosine A2A receptor A2AR antagonist IC50=29 nM . A2AR-antagonist-1 exhibits anti-tumor activity and mouse liver microsomal metabolic stability t1/2=86.1 min . A2AR-antagonist-1 is also a T cells activator, via inhibiting immunosuppressive molecules LAG-3 and TIM-3 and enhancing effector molecules GZMB, IFNG, and IL-2 .
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