GENERAL CATALOGUE
AB3067
HY-170390 · 50 mg
MedChemExpress · Cat: HY-170390
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medchemexpress.com/ab3067.html
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Catalog No: HY-170390
Category: Epigenetics
Pack Size: 50 mg
Brand: MedChemExpress
Description
AB3067 is a PROTAC degrader for BET protein, that recruits two different E3 ligase Cereblon and VHL with good affinity IC50=559 nM for VHL in live HEK293; IC50=190 nM for CRBN in live HEK293 , and degrades BRD2, BRD3, BRD4 and CRBN with DC50 of 2.12.3, 1.6, 15 and 75 nM, respectively. AB3067 inhibits the proliferation of RKO cell with an EC50 of 111 nM. Pink: ligand for target protein HY-131633A ; Black: linker HY-170391 ; Blue: ligand for E3 ligase VHL HY-112078 and CRBN HY-W998346
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