GENERAL CATALOGUE
ABT-737-d8
HY-50907S · 100 g
MedChemExpress · Cat: HY-50907S
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medchemexpress.com/abt-737-d8.htmlCatalog No: HY-50907S
CAS No: 1217686-68-4
Pack Size: 100 g
Brand: MedChemExpress
Description
ABT 737-d8 is the deuterium labeled ABT-737. ABT-737, a BH3 mimetic, is a potent Bcl-2, Bcl-xL and Bcl-w inhibitor with EC50s of 30.3 nM, 78.7 nM, and 197.8 nM, respectively. ABT-737 induces the disruption of the BCL-2/BAX complex and BAK-dependent but BIM-independent activation of the intrinsic apoptotic pathway. ABT-737 induces autophagy and has the potential for acute myeloid leukemia AML research.
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