GENERAL CATALOGUE
ABT-737
HY-50907 · Free Sample (0.1 - 0.2 mg)
MedChemExpress · Cat: HY-50907
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medchemexpress.com/abt-737.html
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Catalog No: HY-50907
CAS No: 852808-04-9
Category: Apoptosis
Pack Size: Free Sample (0.1 - 0.2 mg)
Brand: MedChemExpress
Description
ABT-737, a BH3 mimetic, is a potent Bcl-2, Bcl-xL and Bcl-w inhibitor with EC50s of 30.3 nM, 78.7 nM, and 197.8 nM, respectively. ABT-737 induces the disruption of the BCL-2/BAX complex and BAK-dependent but BIM-independent activation of the intrinsic apoptotic pathway. ABT-737 induces autophagy and has the potential for acute myeloid leukemia AML research.
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