GENERAL CATALOGUE
ABT-751
HY-13270 · Free Sample (0.1 - 0.2 mg)
MedChemExpress · Cat: HY-13270
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medchemexpress.com/ABT-751.html
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Catalog No: HY-13270
CAS No: 141430-65-1
Category: Apoptosis
Pack Size: Free Sample (0.1 - 0.2 mg)
Brand: MedChemExpress
Description
ABT-751 E7010 is a novel, highly orally bioavailable sulfonamides antimitotic compound and tubulin binder. It prevents tubulin aggregation by binding to the colchicine site on ?-tubulin, leading to cell cycle arrest in G2/M phase and inducing apoptosis, thus effectively preventing cell division. ABT-751 induces autophagy by inhibiting the AKT/MTOR signaling pathway. ABT-751 showed significant inhibition against various types of cancer cells, including lung, gastric, colon, and breast cancer.
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