ACBI3

Description

ACBI3 compound 7 , a chemical probe, is a PROTAC targeting KRAS. ACBI3 is composed of PROTAC target protein ligand pan-KRAS degrader 1 HY-162960 red part , E3 ligase ligand E3 ligase Ligand 43 HY-401613 blue part and PROTAC Linker 1-Bromo-4- ethynyloxy butane HY-169992 black part , among which the conjugate of E3 ubiquitin ligase ligand + Linker is E3 Ligase Ligand-linker Conjugate 143 HY-169995 . ACBI3 achieves in vivo degradation of oncogenic KRAS, resulting in durable pathway modulation and tumor regressions in KRAS mutant xenograft mouse models.