Ace-1 Cells (Luciferase Transduced)

Description

Ace-1 cells were derived from a dog with spontaneous prostate cancer. Ace-1 cells metastasize primarily to the appendicular and axial skeleton after injection into the left cardiac ventricle in mice. Ace-1 cells can be xenografted to immunosuppressed laboratory beagles. The Ace-1 cell line demonstrates marked epithelial-mesenchymal transition and produces mixed osteoblastic and osteolytic metastases. Cells have been transduced with a luciferase reporter which allows for monitoring of tumor growth using bioluminescent imaging. The Ace-1 cells can be used to develop an experimental model of prostate cancer in immunosuppressed dogs to investigate molecular imaging, focal therapy of prostate cancer, and metastasis to lymph nodes, lungs and bone.