AChE/BChE-IN-23

Description

AChE/BChE-IN-23 Compound 6e is an AChE/BChE inhibitor IC50: 0.91 ?M, 1.19 ?M and 1.01 ?M for hAChE, eq BChE and hBChE, respectively . AChE/BChE-IN-23 has antioxidant activity and inhibits A?1-42 and Tau protein aggregation. AChE/BChE-IN-23 also inhibits microglial activation by reducing ROS release and mitochondrial injury. AChE/BChE-IN-23 suppresses NLRP3 inflammasome and pro-inflammatory cytokines in human microglial cells. AChE/BChE-IN-23 also reverses the Scopolamine HY-N0296 -induced memory impairment in mice model.